Carbamazepine treatment of generalized tonic–clonic seizures in idiopathic generalized epilepsy

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Carbamazepine treatment of generalized tonic–clonic seizures in idiopathic generalized epilepsy

PURPOSE Evaluate the efficacy of carbamazepine in the treatment of idiopathic generalized epilepsy (IGE). METHOD The response of five patients with IGE, who experienced primarily generalized tonic-clonic seizures which were refractory to multiple antiepileptic drugs, is reported. RESULTS Carbamazepine controlled multiple seizure types and did not induce or increase the frequency of myocloni...

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Automatisms in absence seizures in children with idiopathic generalized epilepsy.

BACKGROUND Automatisms are well recognized to occur in complex partial seizures; however, their occurrence in generalized epilepsies is not always appreciated. There has been considerable debate regarding the nature, triggers, and timing of automatisms in absence seizures. OBJECTIVES To examine the frequency and nature of automatisms in new-onset absence seizures and assess the influence of t...

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Perampanel for tonic-clonic seizures in idiopathic generalized epilepsy

OBJECTIVE To assess efficacy and safety of adjunctive perampanel in patients with drug-resistant, primary generalized tonic-clonic (PGTC) seizures in idiopathic generalized epilepsy (IGE). METHODS In this multicenter, double-blind study (ClinicalTrials.gov identifier: NCT01393743; funded by Eisai Inc.), patients 12 years or older with PGTC seizures and IGE were randomized to placebo or peramp...

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Immunological Correlates of Adult Onset Idiopathic Generalized Tonic-clonic Epilepsy before and after Sodium Valproate Treatment

Objective: To investigate possible immunological humoral correlates in newly diagnosed adult-onset generalized tonic-clonic epilepsy among Iranian patients before and after sodium valproate treatment.   Patients and Methods: 72 adult patients with newly diagnosed idiopathic generalized tonic-clonic epilepsy were recruited. Serum antinuclear antibodies (ANA), anti-cardiolipin antibodies (aCL), a...

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Cerebellum Abnormalities in Idiopathic Generalized Epilepsy with Generalized Tonic-Clonic Seizures Revealed by Diffusion Tensor Imaging

Although there is increasing evidence suggesting that there may be subtle abnormalities in idiopathic generalized epilepsy (IGE) patients using modern neuroimaging techniques, most of these previous studies focused on the brain grey matter, leaving the underlying white matter abnormalities in IGE largely unknown, which baffles the treatment as well as the understanding of IGE. In this work, we ...

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ژورنال

عنوان ژورنال: Seizure

سال: 2014

ISSN: 1059-1311

DOI: 10.1016/j.seizure.2013.11.016